r63534, VBox 4.2.16.
Got the game from: http://www.bestoldgames.net/legend-of-kyrandia
The game looks quite fine except the text. That is glitched (see screenshots). The dialogues are glitched, also the location/action bar (right above the inventory) and the error log (says something about missing temp.del)
You may need to run setup.exe and select "no mouse" amongst the options, the mouse cursor is controlled by arrows and clicking is done by spacebar then. Game is started by main.exe. I wasn't able to control the cursor using mouse even when enabled in setup.exe.